Workforce, training and education
Yorkshire and Humber

Placements and Training Opportunities

 

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Sunset over the Humber Bridge

During your registrar training you will spend time in district general hospitals and larger teaching hospitals to gain a range of haematology experience in both malignant and non-malignant clinical haematology, as well as laboratory haematology. Both district general hospital and teaching hospital placements will provide exposure to many of the key aspects of haematology, including inpatient and outpatient management of myeloma, lymphoma, acute and chronic leukaemias, haemolytic disorders, to name just a few. You will also have ample opportunity to review and report blood films.

 

 

 

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Rainbow over Cottingham, location of Castle Hill Hospital, Hull

In addition you will have the opportunity to obtain some subspecialty experience in particular areas of haematology that you may not otherwise be involved with on a day-to-day basis. These include: specialist coagulation, allogeneic stem cell transplant (BMT), transfusion medicine, haematopathology (HMDS), and paediatrics.

 

 

Click on the tabs below to find out more about haematology training.

 

 

 

 

BMT

Despite advances in immunochemotherapy for haematological malignancies, for many diseases, especially at relapse, allogeneic stem cell transplant still represents the only potentially curative option for those patients fit enough to undergo this and for whom a suitable donor has been identified. You will spend 4 months on the transplant team, learning how to manage inpatients going through the transplant process, following up post-transplant patients in the outpatient clinics, learning about transplant-related complications, undertaking pre-assessment and consent for allogeneic stem cell transplant, and producing the individual patient transplant timetables that define each individual's conditioning regimen, transplant date, medications and post-transplant course. The patients are profoundly immunosuppressed and are suscpetible to many opportunistic pathogens including disseminated fungal infection. They also have a risk of graft-versus-host disease, sinusoidal obstructive syndrome and other chemotherapy-related organ damage. BMT rotation can be emotionally demanding but provides an excellent learning opportunity.

Haematopathology (HMDS)

The Haematological Malignancy Diagnostic Service (HMDS) based at St James's Hospital in Leeds provides a comprehensive haematopathology service across the Yorkshire region, also receiving referrals from further afield and acting as a diagnostic reference centre for a number of national and international clinical trials.

Spending time with the HMDS team, you will see how pathology specimens are processed, learn about the laboratory techniques - flow cytometry, fluorescence in situ hybridisation (FISH), gene expression arrays, PCR and sequencing-based methods, SNP arrays, histology and immunohistochemistry - and have the opportunity to improve your ability to interpret and report bone marrow aspirates and trephines, lymph nodes, spleens and many other types of tissue biopsy.

The HMDS website also has links to educational events, explanations of some of the laboratory techniques employed, and classical case examples.

Malignant haematology

Malignant haematology encompases myeloid disorders, such as acute and chronic leukaemias, myelodysplastic syndromes and myeloproliferative neoplasms; lymphoma, of which there are many subtypes; and myeloma and other plasma cell dyscrasias. You will manage patients with these conditions both in the inpatient and outpatient setting, dealing with complications relating to the disease process itself and treatment. Many of these patients will be receiving intensive chemotherapy and require close monitoring, particularly for complications such as neutropenic sepsis. Several myeloma and lymphoma patients will also undergo autologous stem cell transplantation, a process that always requires an inpatient stay.

 

You will also attend MDT meetings in which patients with new or relapsed diagnoses are discussed and treatment plans put in place. Presenting patients at these meetings is an excellent way to learn and to appreciate the options available for treatment at different stages of the disease process.

 

Non-malignant haematology

Non-malignant haematology encompasses a wide range of benign and not-so-benign conditions. These may be congenital, such as the haemoglobinopathies, red cell membrane or enzyme disorders, or some of the bone marrow failure syndromes; or they may be acquired, such as autoimmune haemolytic anaemia, immune thrombocytopenia or thrombotic microangiopathies. Despite the umbrella term "non-malignant haematology", many of these conditions can be life-threatening emergencies such as a sickle cell acute chest crisis or thrombotic thrombocytopenic purpura.

You will be looking after these patients in teaching hospitals and district general hospitals, both as inpatients with acute complications and as outpatients for routine monitoring.

Paediatrics

Many of the haematological conditions that occur in the adult population present and behave differently in infants, children and teenagers and young adults. Treatment modalities are different, as is prognosis. In addition there are many first presentations of hereditary disorders such as haemophilia A and B and other bleeding disorders, haemophagocytic lymphohistiocytosis and congenital bone marrow failure syndromes such as Diamond-Blackfan anaemia and Schwachman-Diamond syndrome. This is also an opportunity to see haemoglobinopathy patients as children, providing vital insight into their experiences and how this can impact them as they transition to adulthood.

PNH

The Leeds PNH team is renowned worldwide for their expertise in managing patients with this condition. The team provide a national outreach service and you will have the opportunity to join them for outreach clinics across the country, including Southampton, Bristol, Peterborough, Monklands, Oxford, Manchester, Liverpool and Birmingham.

You will learn about the pathogenesis of this rare condition, its complications, and treatment options. Many of the complications of PNH, such as thrombosis, pulmonary hypertension, uncontrolled haemolysis and renal failure are now potentially preventable with the advent of complement inhibition in the form of Eculizumab.

As PNH is often associated with aplastic anemia, you will also gain experience in the inpatient and outpatient management of patients with this condition too.

Specialist coagulation

Whether you want to be a specialist in coagulation or not, many of the general on call haematology questions and cases that you will be contacted about relate to problems with haemostasis and thrombosis. Whether it is a patient with congenital haemophilia A who needs an elective hip replacement, a pre-op cancer patient found to have sheet bruising and a severely prolonged APTT, a baby with purpura fulminans, a pregnant female with type 2B von Willebrand's disease, a 63 year-old lady who is anticoagulated following an acute PE but who now needs urgent surgery, or an elderly man taking rivaroxaban who has a traumatic subdural haemorrhage, you will need to understand the issues involved and be able to formulate an effective management strategy. Having a good understanding of the laboratory aspects of the coagulation assays is vital to being able to correctly interpret results and request the appropriate investigations.

You will gain considerable coagulation epxerience as part of your day-to-day haematology training and on calls.  In addition there is a placement or secondment to the specialist coagulation services, providing further opportunity to learn about specialist laboratory coagulation and review patients with particularly complex clotting problems. 

Transfusion

NHS Blood and Transplant (NHSBT) looks after blood donation services in England and transplant services across the UK. This includes all stages from donation through to correct storage and allocation of blood, organs, tissues, bone marrow and stems cells as well as investigation following adverse reactions. Hospital transfusion teams must liase closely with NHSBT, red cell immunohaematology (RCI) reference labs - which provide more detailed serological investigation of samples referred by hospital transfusion laboratories as well as antenatal services - and the therapeutic apheresis service (TAS) - which provides a 24 hour plasma and red cell exchange service for a range of haematological and non-haematological conditions as well as facilitating planned stem cell harvests.

Having a working knowledge of laboratory transfusion medicine as well as the guidelines and routes for mandatory haemovigilance reporting are an important part of clinical haematology. How to perform a cross match, how to identify an alloantibody, what the process of an adsorption or an elution involves, checking for foeto-maternal haemorrhage and advising on anti-D immunoglobulin.......all form part of transfusion medicine. Familiarity with relavant regulatory bodies such as SHOT (Serious Hazards Of Transfusion), SABRE (Serious Adverse Blood Reactions and Events), MHRA (Medicines and Healthcare products Regulatory Agency) and JPAC (Joint UKBTS Joint Professional Advisory Committee) also forms part of your training in transfusion medicine.

 

CAR-T Therapy

St James's Hospital is one of the centres within the UK delivering CAR-T therapy and during your time at St James's Hospital you will be involved with the CAR-T service, in particular managing the CAR-T inpatients when on call or as part of your routine work within the lymphoma and BMT teams. Patients with relapsed/refractory diffuse large B cell lymphoma, transformed follicular lymphoma, primary mediastinal B cell lymphoma, or mantle cell lymphoma may be eligible.

CAR-T therapy has several stages:

  • Initial work-up and assessment of eligibility
  • Approval of eligibility via the National CAR-T Panel
  • Apheresis/collecting the T cells
  • Manufacture of the CAR-T product
  • Conditioning chemotherapy
  • Infusion
  • Monitoring and treatment of acute complications - specifically for Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)
  • Follow–up

CAR-T video

 

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